efficacy of urinary hippuric acid as a biomarker of low level exposure to toluene in petroleum depot workers
نویسندگان
چکیده
exposure to toluene can be associate with genotoxicity, neurological dysfunction, reproductive toxicity, and etc. biomonitoring of hippuric acid (ha) is used for a long time as an occupational exposure index to toluene. the aim of this study was to explore efficiency of ha as a biomarker of exposure to low level of toluene for iranian petroleum depot workers in 2011. personal monitoring to toluene exposure for 45 workers (exposed group) and 32 staff (control group) were done according to the niosh method no.1501, and simultaneous biological monitoring were conducted as urinary ha for all subjects. pre and post shift urine samples were collected for analysis of ha by the niosh method no.8300 and urinary ha concentrations were corrected with creatinine content. personal exposure of petroleum loading operators to toluene was 0.78±0.37ppm (mean±se). there was no statistical significant difference between urinary ha of exposed and control groups (staff). there was no statistical correlation between occupational exposure to toluene and internal exposure in term of ha. occupational exposures to toluene were less than tlv in petroleum products loading operators. due to exposure with low levels of toluene concentrations, however the content of urinary ha in gasoline operators were higher than bei (biological exposure index), but of no significant relationship between airborne concentrations of toluene and levels of ha in urine in all exposed groups. in conclusion, urinary ha is not appropriate biomarker of low level exposure to toluene.
منابع مشابه
Evaluation of Toluene Exposure in Workers at Industrial Area of Sidoarjo, Indonesia by Measurement of Urinary Hippuric Acid
Background: Toluene is a harmful substance still being used as a solvent and catalyst in many industries that can increase the level of urinary hippuric acid (UHA). This study was designed to examine the level of toluene and UHA among workers of industrial site in seven companies in Sidoarjo, Indonesia and to analyze the risk factors for abnormal UHA. Methods: This study was an analytical cross...
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The results of industrial investigations have shown a correlation between the rate of hippuric acid excretion in a single urine sample collected after daily occupational exposure and the amount of toluene absorbed. The rate of hippuric acid excretion and the average concentration of toluene vapour during exposure time were also related. The quantitative range of the test has been limited to amo...
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Introduction: Toluene is an organic solvent that it is one of the byproducts in the coke industry. Exposure to toluene causes central nervous system dysfunction and others disorders. Many workers are exposed to toluene due to leakage from tracks. Therefore the aim of this study was to determine the levels of exposure through environmental and biological monitoring of toluene Methods: Air tol...
متن کاملOccupational exposure of petroleum depot workers to BTEX compounds.
BACKGROUND Benzene, toluene, ethylbenzene and xylene (BTEX) are the most important toxic volatile compounds in the air and could be easily absorbed through the respiratory tract. In recent years, the risk of exposure to BTEX compounds, especially benzene as a carcinogen, has been considered in petroleum depot stations. OBJECTIVE To assess the occupational exposure of petroleum depot workers i...
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عنوان ژورنال:
international journal of occupational hygieneجلد ۵، شماره ۳، صفحات ۱۳۹-۱۴۳
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